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University of Groningen A novel membrane protein insertion pathway in Escherichia coli van der Laan, Martin IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below. Document Version Publisher's PDF, also known as Version of record Publication date: 2004 Link to publication in University of Groningen/UMCG research database Citation for published version (APA): van der Laan, M. (2004). A novel membrane protein insertion pathway in Escherichia coli Groningen: s.n. Copyright Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons). Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum. Download date: 01-02-2018 A novel membrane protein insertion pathway in Escherichia coli 2Dear Faculty and Staff, The Office of Student Disabilities (SDS) is pleased to announce some new procedures for students with disabilities taking exams at the SDS testing center. For a complete description of our policies, please go to: http://www.ccsu.edu/sds/examPolicy.html. When you have students who need an exam at the testing center: 1. Students start the process by contacting SDS personally. 2. Students must fill out a Test Request Form at least 3-7 business days prior to the exam. 3. This initiates an e-mail to the faculty member. Faculty fill out information about the exam and send that information plus the exam to SDS. This can be done by fax, campus mail, in person, or through email. 4. Faculty indicate how they would like the exam returned to them. 5. All students are proctored during the exam. Every now and again, faculty might like to have access to the Test Request Form for Faculty ahead of time to send over the exams for students before the student sets up an appointment to take the exam. Therefore, we have provided a copy of the Test Request Form for Faculty. If a student is receiving accommodations and does not have an appointment, even if the test is available at SDS, we will not be able to allow the student access to the testing center. We have many more students taking their exams at SDS and our space is limited. An appointment ensures that every student will have access to the center. For any questions about students with disabilities, please do not hesitate to contact our office. Please see the next page for a copy of the Test Request Form for Faculty. If you are receiving this Exam Proctoring Checklist via email, click REPLY, then complete the information below, attach the exam, and click SEND to transmit your information to DisabilityServices@ccsu.edu. OR Click on REPLY, complete, print and select an alternative method of exam delivery. Last: First: Course/Instructor: Date/time of exam: What is the time allotted for students taking the exam in class? Please check all items that are permitted in the test area: open book notes calculator formula sheet scrap paper Blue Book (s) Scantron Sheet(s) other (PLEASE EXPLAIN) If a question may arise during the exam, please list the name and phone number of instructor or designee who will be available during the time the student taking the exam. Instructor/Designee: Phone: For on-line exams, please provide details required to facilitate the exam session: Exam delivery: E-mail the exam with this completed form to DisabilityServices@ccsu.edu Fax the exam to: 860-832-1865 Drop off the exam to SDS (Carroll Hall 150). Exam return: Faculty or department secretary will pick up exam from SDS (Carroll Hall 150). Send by campus mail to this department: Scan completed exam to faculty e-mail (Exam must be on single-sided 8.5X11 paper; cannot scan exams with Blue Books) Signature/Date at time of exam pick up from SDS (Carroll 150). Signature: __________________________________ Date:________________________ Dedicated to my grandfather Theodor Specht (1921-1996) "Nothing on earth stays forever, but none of your deeds were in vain. Deep in our hearts you will live again, you've gone to the home of the brave" Joachim Cans (1997) Cover: The thinker, clay sculpture by Sandra Kuiper (original by Auguste Rodin, 1882) Photography taken by Photo Brockshus, Bremen This work was carried out in the Molecular Microbiology Group of the Groningen Biomolecular Sciences and Biotechnology Institute (GBB) of the University of Groninngen, The Netherlands, and was financially supported by the Council for Earth and Life Sciences of the Netherlands Organization for Scientific Research (ALW-NWO) and was subsidized by the Dutch Organization for the Advancement of Scientific Research (NWO). 3 RIJKSUNIVERSITEIT GRONINGEN A novel membrane protein insertion pathway in Escherichia coli Proefschrift ter verkrijging van het doctoraat in de Wiskunde en Natuurwetenschappen aan de Rijksuniversiteit Groningen op gezag van de Rector Magnificus, dr. F. Zwarts, in het openbaar te verdedigen op vrijdag 10 september 2004 om 14.45 uur door Martin van der Laan geboren op 13 maart 1974 te Leer, Duitsland 4 Promotor : Prof dr. A.J.M. Driessen Copromotor : dr. N.P. Nouwen Beoordelingscommissie: Prof. dr. B. Poolman Prof. dr. L. Dijkhuizen Prof. dr. B. Oudega 5 Preface So finally, this little book is ready to be printed and I may look back on the four exciting years of my life that I spent in Groningen and worked in the Department of Molecular Microbiology at the Biological Centre in Haren. When I think about all the blood, sweat and tears, but also about the triumph and joy, the heart and the soul that lie hidden between all the following lines and pages, some great people come to my mind, who accompanied, supported and guided me on this long and winding road. I want you to know that I am very grateful to all of you and that I wish you good luck and success for the future. May all your dreams come true ! Arnold, my promotor, I would like to thank you for a very pleasant, instructive and scientifically productive time. It was the open-minded, creative and stimulating atmosphere that I experienced in your lab during my visit as a student back in 1998 that hooked my heart up on science. During my years as a PhD student, you always found an excellent balance between guidance and freedom. Your trust and confidence was a solid basis for me to develope as a scientist and as a person. You somehow always knew when to push me, when to comfort me, when to hold me back. You shared your experience and your enthusiasm with me and gave me the time and scope to grow. Nico, my copromotor, your contribution to this thesis is immense. Your energy, your motivation, your ideas for new experiments and your critical view on my work were extremely important and helpful for me. I learned so many things from you, but above all the realistic interpretation of my own data. It was a pleasure to work with you in A252 and I thank you very much for everything ! Eli, my paranimf and lab mate, I really enjoyed working, cursing and laughing with you and I highly esteem your deep scientific insight and understanding. Your interest in "hardcore" biochemistry and my interest in cell biology complemented one another perfectly in approaching a problem together. And I appologize for calling your music "melody-free noise"... Rock on, dude ! Bastiaan and Dirk-Jan, my great friends, plain and simple words can hardly describe, what we share. Our discussions and brainstormings about science, about God and the 6 ways of the world, about politics and life in general, about music, literature and all the other things that make life a little bit more worth living, and last but not least about our love and our dreams were a wonderful and everflowing source of inspiration and motivation for me. You were with me in triumph and defeat, you suffered and exulted with me and you were always upright and honest. For me, you are two of the few real friends that a man meets in his life and I hope that we never loose contact... 'til death do us part ! Andreas, my brother in metal, I will never forget the long evenings (Should I say nights...?) we spent together with our good ol' friend Remy Martin (Remember his tasteless and boring little brother... ?) listening to the greatest music in the world and discussing about the four most important things in life: science, philosophy, love and heavy metal music !! I think we know a lot about each other, things we normally bury deep in our hearts. I wish you all the best on your future ways, wherever they may lead you. In union we stand to keep the fire burning ! My dear fellow Molmix, colleagues and friends, I would like to thank you for the excellent atmosphere in the lab, for all the discussions and the fun that we had together. You are too numerous to mention you all, but I would like to name a few, who have a special place in my memory and in my heart: Chris ("Deutsch sprechen macht Spaß."), Sonja (Thanks for the philosophic morning coffees and the chances to release some steam from my mental boiler every now and then!); Jeanine ("Sec in black" rules!), Jelto (my patient as wise first supervisor), Danka (The sunshine of our office), Janny (drill instructor with a heart of gold), Titia ("Gravity ?" – "Checked !"), Philipp (The JCB paper is your baby, thanks for working with me !), Ilja (our brave Don Quixote fighting the SPR wind mill...), Oscar (my isotopia labmate), Bea & Manon (the wonderful femmes fatales from the secretariate, who saved my nerves so many times) and Juke (always willing to discuss the wildest ideas and theories with me – thanks !). During my time in Groningen, I also had the opportunity to work in the labs of Ben de Kruijff in Utrecht and Joen Luirink in Amsterdam. These fruitful cooperations resulted in several joint publications. For me, this was a very exciting and instructive experience and I would like to thank everybody, who was involved in these projects, especially Edith, Malene and Ronald from the VU. We had a perfect time together, scientifically as well as personally, and a lot of great fun ("Ga je meee, naar het ErEnCeeee....!"). 7 Very special thanks also go out to you, Katja, for your true friendship and care, for all the exciting hours we spent together and for all the high quality lunches and dinners. And never ever forget: Cats don't belong on the table – at least not during the meals ! Einen ganz besonders herzlichen und warmen Dank möchte ich einigen lieben Menschen aussprechen, die mich schon seit so vielen Jahren mit ihrer Unterstützung und Liebe durch mein Leben begleiten. Meine Eltern, Gerda und Dirk, ich danke Euch für Euer Vertrauen, für Eure Hilfsbereitschaft und dafür, dass Ihr mir die Zuversicht gebt, dass ich mich immer auf Euch verlassen kann. Es springt sich leichter in einen neues Abenteuer, wenn man weiss, dass da jemand ein Netz unter einem aufgespannt hat. Thomas, mein kleiner großer Bruder, ich danke Dir für zahllose wichtige und gute Gespräche, für Deinen exzellenten Musikgeschmack und für die Herzlichkeit und Zuneigung, mit der Du mir begegnest. Du wirst Deinen Weg machen, da bin ich mir ganz sicher. Zeig's Ihnen ! Meike, meine beste Freundin, ich bin beinahe geneigt zu schreiben, meine große Schwester, die ich nie hatte. Unsere Freunschaft hat nun schon fast zwanzig Jahre überdauert und ich möchte Dir ganz herzlich dafür danken, dass es Dich gibt, und dass Du in all den Jahren trotz großer räumlicher Distanz den Kontakt zu mir immer wieder gesucht hast. Du bist ein wunderbarer und überaus wertvoller Mensch ! Bis zum Ende habe ich mir den wichtigsten Menschen in meinem Leben aufgespart. Sandra, meiner kleiner Tiger, ich danke Dir sehr für Deine Wärme und Liebe, für Deine Unterstützung und Dein Verständnis, für Deine verrückten Ideen und dafür, dass Du tatsächlich mit mir Chaot alt werden willst. Ich liebe Dich ! Euer Martin Kirchzaren, 11.07.2004 8 10
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